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KMID : 0921620160460010022
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Journal of Bacteriology and Virology
2016 Volume.46 No. 1 p.22 ~ p.26
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Application of Diagnostic Microarray Technique in Subtyping and Pathotyping of Avian Influenza Viruses Isolated in Mongolia
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Kwon Jung-Hoon
Kim Ji-Hoon
Lee Dong-Hun
Cho Hyun-Seok
Hwang Seung-Yong
Yuk Seong-Su
Tseren-Ochir Erdene-Ochir
Noh Jin-Yong
Hong Woo-Tack
Jeong Jei-Hyun
Jeong Sol
Gwon Gyeong-Bin
Lee Sang-Won
Choi In-Soo
Song Chang-Seon
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Abstract
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Asian-lineage H5 highly pathogenic avian influenza (HPAI) viruses have caused continuous outbreaks in poultry and wild birds. Development of rapid and accurate diagnostic methods is needed for preventing further spread of the virus and reducing the time required for eradication of the virus. We developed a low-density microarray for the rapid detection and identification of avian influenza virus subtypes H5, H7, and H9 and their pathotypes in a previous study. In the present study, we evaluated previously developed diagnostic microarray using avian influenza viruses isolated in Mongolia, including H5 HPAI viruses. All H5 HPAI viruses isolated in Mongolia were shown as H5-specific and highly pathogenic pattern in the microarray. H2, H3 and H12 viruses isolated in Mongolia used in this study did not show any H5, H7 and H9 patterns. These results indicated that this diagnostic microarray has enormous potential for the rapid subtyping and pathotyping of influenza viruses, including viruses isolated in Mongolia.
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KEYWORD
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Influenza virus, HPAI, Microarray, Mongolia, Rapid diagnosis
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